Human Mitochondrial RNA Processing and Modifications: Overview
| Autor: | Roman J. Szczesny, Agata Jabczynska, Marta Jedynak-Slyvka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Mitochondrial RNA processing
Mitochondrial DNA RNA Mitochondrial QH301-705.5 Review Mitochondrion Biology DNA Mitochondrial RNA decay Catalysis Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine RNA modifications Organelle Humans mitochondrial transcription RNA Processing Post-Transcriptional Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy 030304 developmental biology 0303 health sciences Innate immune system Organic Chemistry Translation (biology) General Medicine Computer Science Applications Cell biology mitochondria Chemistry chemistry RNA processing Apoptosis mitochondrial genome Adenosine triphosphate 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 7999, p 7999 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are present in almost all eukaryotic organisms, including humans. They are the key energy suppliers as the site of adenosine triphosphate production, and are involved in apoptosis, calcium homeostasis, and regulation of the innate immune response. Abnormalities occurring in mitochondria, such as mitochondrial DNA (mtDNA) mutations and disturbances at any stage of mitochondrial RNA (mtRNA) processing and translation, usually lead to severe mitochondrial diseases. A fundamental line of investigation is to understand the processes that occur in these organelles and their physiological consequences. Despite substantial progress that has been made in the field of mtRNA processing and its regulation, many unknowns and controversies remain. The present review discusses the current state of knowledge of RNA processing in human mitochondria and sheds some light on the unresolved issues. |
| Databáze: | OpenAIRE |
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