Synthesis of novel organohalogen chalcone derivatives and screening of their molecular docking study and some enzymes inhibition effects
| Autor: | Mustafa Zahrittin Kazancioglu, Ruya Kaya, Muhammet Karaman, İlhami Gülçin, Serdar Burmaoglu, Elif Akin Kazancioglu, Oztekin Algul |
|---|---|
| Přispěvatelé: | Belirlenecek |
| Rok vydání: | 2020 |
| Předmět: |
Chalcone
Alpha-Glycosidase Carbonic anhydrase II Anticholinergic Activities 010402 general chemistry 01 natural sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound Isoenzymes I Carbonic anhydrase Carbonic Anhydrase I Receptor Spectroscopy chemistry.chemical_classification Crystal-Structure biology 010405 organic chemistry Organic Chemistry Potent Carbonic-Anhydrase Active site 1st Synthesis Acetylcholinesterase Trout Oncorhynchus-Mykiss 0104 chemical sciences Enzyme inhibition Enzyme chemistry Biochemistry Hca I biology.protein Biological Evaluation Erythrocytes In-Vitro |
| Zdroj: | Journal of Molecular Structure. 1208:127868 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2020.127868 |
| Popis: | Chalcones and their derivatives are increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel organohalogen chalcone derivatives (5-12) were tested towards alpha-glycosidase (alpha-Gly), acetylcholinesterase (AChE) human carbonic anhydrase I (hCA I), and carbonic anhydrase II (hCA II) enzymes. These compounds (5-12) showed K,s in ranging of 16.24 - 40.96 nM on hCA I, 29.61-67.15 nM on hCA II, 1.21-4.39 nM on AChE and 12.54-35.22 nM on alpha-glycosidase. The novel organohalogen chalcone derivatives (5-12) had effective inhibition profiles against all tested metabolic enzymes. Also, because of the enzyme inhibitory effects of the compounds (5-12), they have the potential of drug candidates to treat of some diseases including epilepsy, glaucoma, type-2 diabetes mellitus (T2DM), Alzheimer's disease (AD), and leukemia. Also, the chalcone derivatives with best inhibition score docked into the active site of indicated metabolic enzymes receptors. Bro-mobenzyle and chlorophenyl moieties of chalcone derivatives contribute to their inhibitor properties on the enzymes. (C) 2020 Published by Elsevier B.V. |
| Databáze: | OpenAIRE |
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