Activation and modulation of calcium-activated non-selective cation channels from embryonic chick sensory neurons
| Autor: | L. D. Partridge, Seddigheh Razani-Boroujerdi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cytoplasm
chemistry.chemical_element Chick Embryo Calcium Ion Channels Cations Ganglia Spinal medicine Animals Patch clamp Neurons Afferent Protein kinase A Molecular Biology Ion channel Chemistry General Neuroscience fungi Osmolar Concentration food and beverages Cyclic AMP-Dependent Protein Kinases Sensory neuron Electrophysiology medicine.anatomical_structure Biophysics Phosphorylation Ligand-gated ion channel Neurology (clinical) Neuroscience Developmental Biology |
| Zdroj: | Brain research. 623(2) |
| ISSN: | 0006-8993 |
| Popis: | We have shown that calcium-activated non-selective (CAN) channels from embryonic chick sensory neurons are permeable to both Na+ and K+ and are not blocked by TTX, TEA, or 4-AP. These neuronal CAN channels are activated by sub-micromolar cytoplasmic Ca2+ with negative cooperativity. The effect of Ca2+ is to decrease the closed times of the channel with little effect on the time the channel remains open. Isolated neuronal CAN channels can be phosphorylated by cAMP-dependent protein kinase (PKA). The effect of phosphorylation is to shorten channel open time and to minimize the effect of Ca2+ on channel closed time. |
| Databáze: | OpenAIRE |
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