Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference
| Autor: | J. Harts, Ting-Kai Li, L. Lumeng, Janice C. Froehlich |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Taste
medicine.medical_specialty Alcohol Drinking Clinical Biochemistry Drinking Behavior Self Administration Toxicology Biochemistry Rats Mutant Strains Behavioral Neuroscience chemistry.chemical_compound Saccharin Reward Oral administration Internal medicine Conditioning Psychological medicine Animals Biological Psychiatry Pharmacology Ethanol preference Ethanol Blood ethanol Rats Alcoholism Endocrinology chemistry Anesthesia Taste aversion Conditioning Female psychological phenomena and processes |
| Zdroj: | Pharmacology, biochemistry, and behavior. 31(1) |
| ISSN: | 0091-3057 |
| Popis: | A conditioned taste aversion (CTA) paradigm was used to determine whether aversion to the pharmacological effects of ethanol, apart from orosensory cues, can contribute to genetic differences in voluntary ethanol consumption. Four doses of ethanol, administered IP, were paired with the consumption of a 0.1% saccharin solution in rats from the alcohol-preferring (P) and alcohol-nonpreferring (NP) lines. Repeated pairings of saccharin and ethanol in a dose of 1.0 g/kg produced stronger and more prolonged aversion to saccharin in NP rats, compared with P rats, at comparable blood ethanol levels. A low dose of ethanol (0.25 g/kg) produced transient conditioned facilitation of saccharin consumption in P rats, but not in NP rats, at comparable blood ethanol levels. The results suggest that rats of the NP line find the postingestional effects of high-dose ethanol more aversive, and low-dose ethanol less reinforcing, than do rats of the P line. Genetic differences in voluntary ethanol consumption may be due, in part, to differences in aversion to the postingestional effects of ethanol. |
| Databáze: | OpenAIRE |
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