Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders
| Autor: | Niccolò Terrando, Ting Yang, Xing-Mei Zhang, Krishna Rao Maddipati, Katerina Akassoglou, Phillip T Newton, S. Mkrtchian, Mattias Carlström, Miles Berger, Robert A. Harris, Mary Cooter, Andrei S. Chagin, G. Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Docosahexaenoic Acids glia medicine.medical_treatment Neurocognitive Disorders Inflammation Bone healing Bone marrow-derived macrophage Pharmacology neuroinflammation 03 medical and health sciences omega 3 fatty acids Fractures Bone Mice 0302 clinical medicine Neuroscience and Neuroanaesthesia medicine postoperative complications Macrophage Maresin Animals Humans Perioperative Period Neuroinflammation 030304 developmental biology Aged Aged 80 and over 0303 health sciences pro-resolving lipid mediators Brain Diseases Cluster of differentiation business.industry Middle Aged 3. Good health macrophages Mice Inbred C57BL Disease Models Animal Anesthesiology and Pain Medicine Cytokine Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | BJA: British Journal of Anaesthesia |
| ISSN: | 1471-6771 0007-0912 |
| Popis: | Background Resolution of inflammation is an active and dynamic process after surgery. Maresin 1 (MaR1) is one of a growing number of specialised pro-resolving lipids biosynthesised by macrophages that regulates acute inflammation. We investigated the effects of MaR1 on postoperative neuroinflammation, macrophage activity, and cognitive function in mice. Methods Adult male C57BL/6 (n=111) and Ccr2RFP/+Cx3cr1GFP/+ (n=54) mice were treated with MaR1 before undergoing anaesthesia and orthopaedic surgery. Systemic inflammatory changes, bone healing, neuroinflammation, and cognition were assessed at different time points. MaR1 protective effects were also evaluated using bone marrow derived macrophage cultures. Results MaR1 exerted potent systemic anti-inflammatory effects without impairing fracture healing. Prophylaxis with MaR1 prevented surgery-induced glial activation and opening of the blood–brain barrier. In Ccr2RFP/+Cx3cr1GFP/+ mice, fewer infiltrating macrophages were detected in the hippocampus after surgery with MaR1 prophylaxis, which resulted in improved memory function. MaR1 treatment also reduced expression of pro-inflammatory cell surface markers and cytokines by in vitro cultured macrophages. MaR1 was detectable in the cerebrospinal fluid of older adults before and after surgery. Conclusions MaR1 exerts distinct anti-inflammatory and pro-resolving effects through regulation of macrophage infiltration, NF-κB signalling, and cytokine release after surgery. Future studies on the use of pro-resolving lipid mediators may inform novel approaches to treat neuroinflammation and postoperative neurocognitive disorders. |
| Databáze: | OpenAIRE |
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