The impact of the type of nodal assessment on prognosis in patients with high-intermediate and high-risk ESMO/ESGO/ESTRO group endometrial cancer. A multicenter Italian study

Autor: Giampaolo Di Martino, Francesca Ciccarone, Fabio Landoni, Giovanni Scambia, Sonia Magni, Francesco Fanfani, Federica Dell'Orto, Giorgia Dinoi, L. Quagliozzi, Alessandro Buda, Stefano Restaino, Giorgia Monterossi, Maria Lamanna, Elena De Ponti
Přispěvatelé: Buda, A, Restaino, S, Di Martino, G, De Ponti, E, Monterossi, G, Dinoi, G, Magni, S, Quagliozzi, L, Dell'Orto, F, Ciccarone, F, Lamanna, M, Scambia, G, Landoni, F, Fanfani, F
Rok vydání: 2018
Předmět:
Oncology
medicine.medical_treatment
0302 clinical medicine
Endometrial cancer
Recurrence risk group
Retrospective Studie
Risk Factors
80 and over
Stage (cooking)
Aorta
Sentinel node mapping
Aortic dissection
Aged
80 and over
030219 obstetrics & reproductive medicine
Lymph Node
General Medicine
Middle Aged
Prognosis
Algorithm
Survival Rate
Italy
030220 oncology & carcinogenesis
Lymphatic Metastasis
Female
Algorithms
Human
Adult
medicine.medical_specialty
Prognosi
Sentinel lymph node
Disease-Free Survival
03 medical and health sciences
Recurrence risk groups
Internal medicine
medicine
Carcinoma
Humans
Endometrial Neoplasm
Survival rate
Aged
Neoplasm Staging
Retrospective Studies
business.industry
Sentinel Lymph Node Biopsy
Risk Factor
Lymphatic Metastasi
Lymphadenectomy
Retrospective cohort study
medicine.disease
Endometrial Neoplasms
Settore MED/40 - GINECOLOGIA E OSTETRICIA
Lymph Nodes
Lymph Node Excision
Surgery
business
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 44(10)
ISSN: 1532-2157
Popis: Objectives The majority of endometrial cancers (EC) are discovered while the disease is confined to the uterine body. The presence of lymph nodes metastases impairs the prognosis. In this study, we evaluated the possible impact on survival of sentinel lymph node (SLN) mapping algorithm and selective lymphadenectomy (LD) in early stage EC, according to the ESMO-ESGO-ESTRO risk subgroup classification. Methods We retrospectively analyzed the database from two collaborative institutions including women with high-intermediate (HI) and high-risk (HR) ESMO/ESGO/ESTRO groups that underwent surgical staging with either SLN mapping, or selective LD. Results Two-hundred and sixty-six women were overall identified, 121 in HI and 145 in HR group, respectively. LD was performed in 139 patients (52.5%), whereas SLN mapping algorithm in 61 patients (23%). Sixty-six patients in Rome center were not staged (24.8%). Aortic dissection was performed in 29 women (10.9%). The 3-year comparison did not show a significant difference between strategy adopted for nodal staging (SLN mapping, LD, and SLN + LD) on both disease-free survival [HR: 0.82; 95% CI 0.53–1.28; p = 0.390], and overall survival [HR: 0.78; 95% CI 0.47–1.31; p = 0.355]. Conclusions In this study focused on women in the HI and HR groups we did not find difference in the 3-years DFS and OS when comparing the SLN strategy with selective lymphadenectomy, or the SLN algorithm. The SLN strategy did not seem to not compromise the prognosis of high risk patients.
Databáze: OpenAIRE
Externí odkaz: