A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span
| Autor: | Matthew J. Peterson, Patrick Sullivan, Miriam C. Morey, Gerda G. Fillenbaum, Virginia B. Kraus, Dana K. Thompson, Carl F. Pieper, Harvey J. Cohen, William E. Kraus |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Aging medicine.medical_specialty Fibrin Fibrinogen Degradation Products 03 medical and health sciences Internal medicine Granulocyte Colony-Stimulating Factor Humans Medicine Interleukin 6 Aged Aged 80 and over biology Interleukin-6 business.industry Middle Aged Adult life Circulating biomarkers 030104 developmental biology Endocrinology Physical Fitness Physical performance Tumor Necrosis Factors biology.protein Female Original Article Observational study Tumor necrosis factor receptor 1 Geriatrics and Gerontology Tumor necrosis factor receptor 2 business Body mass index Biomarkers |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 71:196-202 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glv007 |
| Popis: | Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers would be associated with lower functioning across study populations representing the adult life span. The data were from four intervention and two observational studies with ages ranging 22–89 years. Biomarkers assayed included inflammatory, coagulation, and endothelial function markers. Physical performance was measured either by VO2peak (studies of young and middle-aged adults) or usual gait speed (studies of older adults). Partialled (by age, body mass index, race, and sex) and weighted common correlations were calculated between biomarkers and physical performance. Homogeneity of the associations was also assessed. Interleukin-6 (weighted r = −.22), tumor necrosis factor receptor 2 (weighted r = −.19), D-dimer (weighted r = −.16), tumor necrosis factor receptor 1 (weighted r = −.15), granulocyte colony-stimulating factor (weighted r = −.14), and tumor necrosis factor alpha (weighted r = −.10) were all significantly inversely correlated with physical performance (p < .05). All significant correlations were homogeneous across studies. In summary, we observed consistent inverse associations between six circulating biomarkers and objective measures of physical performance. These results suggest that these serum biomarkers may be broadly applicable for detection, trajectory, and treatment monitoring of physical function across the life span or possibly for midlife predictors of functionally deleterious conditions. |
| Databáze: | OpenAIRE |
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