Update on oogenesis in vitro
| Autor: | Raffaella Fabbri, Maria Macciocca, Chiara Zamboni, Renato Seracchioli, Roberto Paradisi, Rossella Vicenti |
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| Přispěvatelé: | Fabbri R, Zamboni C, Vicenti R, Macciocca M, Paradisi R, Seracchioli R |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject In Vitro Oocyte Maturation Techniques Fertility Oocytes - In-vitro oocyte maturation techniques - Tissue culture techniques - Fertility preservation Oogenesis Andrology Tissue Culture Techniques 03 medical and health sciences Follicle Mice 0302 clinical medicine Ovarian Follicle medicine Autologous transplantation Animals Humans Fertility preservation media_common Cryopreservation Mammals 030219 obstetrics & reproductive medicine business.industry Ovary Obstetrics and Gynecology Fertility Preservation Oocyte 030104 developmental biology medicine.anatomical_structure Oocytes Female Folliculogenesis business |
| Popis: | INTRODUCTION: Ovarian tissue is increasingly being collected from cancer patients and cryopreserved for fertility preservation. Alternately to the autologous transplantation, the development of culture systems that support oocyte development from the primordial follicle stage represent a valid strategy to restore fertility. The aim of this study is to review the most recent data regarding oogenesis in vitro and to provide an up-to-date on the contemporary knowledge of follicle growth and development in vitro. EVIDENCE ACQUISITION: A comprehensive systematic MEDLINE search was performed since February 2018 for English-language reports by using the following terms: "ovary," "animal and human follicle," "in vitro growth and development," "ovarian tissue culture," "fertility preservation," "IVM," "oocyte." Previous published reviews and recent published original articles were preferred in order to meet our study scope. EVIDENCE SYNTHESIS: Over time, many studies have been conducted with the aim to optimize the characteristics of ovarian tissue culture systems and to better support the three main phases: 1) activation of primordial follicles; 2) isolation and culture of growing preantral follicles; 3) removal from the follicle environment and maturation of oocyte cumulus complexes. While complete oocyte in vitro development has been achieved in mouse, with the production of live offspring, the goal of obtaining oocytes of sufficient quality to support embryo development has not been completely reached into higher mammals despite decades of effort. CONCLUSIONS: Over the years, many improvements have been made on ovarian tissue cultures with the future purpose that patients will be provided with a greater number of developmentally competent oocytes for fertility preservation. |
| Databáze: | OpenAIRE |
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