Net influx of plasma 6-[18F]fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli

Autor:	Peter Bartenstein, Hans Georg Buchholz, Dieter F. Braus, Thomas Siessmeier, Karl Mann, Thorsten Kienast, Michael N. Smolka, Mathias Schreckenberger, Jana Wrase, Jennifer Lynne Larsen, Andreas Heinz, Frank Rösch, Paul Cumming
Rok vydání:	2006
Předmět:	Adult Male Fluorine Radioisotopes Dopamine Prefrontal Cortex Striatum Nucleus accumbens Synaptic Transmission Reward system medicine Humans Operculum (brain) Anterior cingulate cortex medicine.diagnostic_test General Neuroscience Ventral striatum Putamen Middle Aged Magnetic Resonance Imaging Corpus Striatum Dihydroxyphenylalanine Dorsolateral prefrontal cortex Affect medicine.anatomical_structure nervous system Positron-Emission Tomography Caudate Nucleus Radiopharmaceuticals Functional magnetic resonance imaging Psychology Neuroscience psychological phenomena and processes Photic Stimulation
Zdroj:	The European journal of neuroscience. 24(1)
ISSN:	0953-816X
Popis:	Dopaminergic neurotransmission in the ventral and dorsal striatum interact with central processing of rewarding and reward-indicating stimuli, and may affect frontocortical-striatal-thalamic circuits regulating goal-directed behaviour. Thirteen healthy male volunteers were investigated with multimodal imaging, using the radioligand 6-[ 18 F]fluoro-L-DOPA (FDOPA) for positron emission tomography (PET) measurements of dopamine synthesis capacity, and also functional magnetic resonance imaging (fMRI) in a cognitive activation paradigm. We calculated the correlation between FDOPA net blood-brain influx (K app in ; ml/g/min) in the ventral and associative dorsal striatum and BOLD signal changes elicited by standardized affectively positive, negative and neutral visual stimuli. The magnitude of K app in in the ventral striatum was positively correlated with BOLD signal increases in the left anterior cingulate cortex and right insular operculum elicited by positive vs. neutral stimuli, but not negative vs. neutral stimuli. In the dorsal striatum, the magnitude of K app in was positively correlated with processing of positive and negative stimuli in the left dorsolateral prefrontal cortex. These findings suggest that dopamine synthesis capacity in the ventral striatum correlates with the attentional processing of rewarding positive stimuli in the anterior cingulate cortex of healthy subjects. Dopaminergic neurotransmission in the associative dorsal striatum has been associated previously with habit learning. The observed correlation between dopamine synthesis capacity in the dorsal striatum and BOLD signal changes in the dorsolateral prefrontal cortex suggests dopaminergic modulation of processing of emotional stimuli in brain areas associated with motor planning and executive behaviour control.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5dd10f87394a26a61dd689106aad64 https://pubmed.ncbi.nlm.nih.gov/16882026 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.