Self-Biting Induced by Activation of L-Type Calcium Channels in Mice: Serotonergic Influences
| Autor: | Kiyoshi Egami, Suhail Kasim, H.A. Jinnah |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Clorgyline Serotonin medicine.medical_specialty Monoamine Oxidase Inhibitors Calcium Channels L-Type Self-biting 5 7-Dihydroxytryptamine Serotonergic Mice Developmental Neuroscience Fluoxetine Internal medicine medicine Animals L-type calcium channel Voltage-dependent calcium channel Chemistry Activator (genetics) Calcium channel Fenclonine Brain 3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester Mice Inbred C57BL Calcium Channel Agonists Biting Endocrinology Neurology Self Mutilation Female Serotonin Antagonists Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Developmental Neuroscience. 24:322-327 |
| ISSN: | 1421-9859 0378-5866 |
| Popis: | The L-type calcium channel activator ±Bay K 8644 has recently been shown to provoke self-injurious biting in young mice. Since the serotonergic systems have been implicated in the expression of self-injurious behavior in both humans and animals, the present studies tested whether drugs influencing serotonin systems could modify the ability of ±Bay K 8644 to cause this behavior. The ability of ±Bay K 8644 to provoke self-biting behavior was increased by the serotonin uptake inhibitor fluoxetine or the monoamine oxidase inhibitor clorgyline. On the other hand, the ability of ±Bay K 8644 to provoke self-biting was decreased by depletion of serotonin with p-chlorophenylalanine or 5,7-dihyroxytryptamine. These results suggest that the ability of ±Bay K 8644 to provoke self-injurious behaviors may be mediated by serotonergic influences. |
| Databáze: | OpenAIRE |
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