Combined use of non-biological artificial liver treatments for patients with acute liver failure complicated by multiple organ dysfunction syndrome
| Autor: | Yan-jun Xu, Jia-qiong Li, Mao-qin Li, Zai-xiang Shi, Xiao-meng Wang, Bo Lu, Yun-hang Zhu, Jun-xiang Ti, Ji-yuan Xu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Hepatitis
Prothrombin time medicine.medical_specialty Pathology medicine.diagnostic_test business.industry Bilirubin medicine.medical_treatment Hemoperfusion medicine.disease Gastroenterology chemistry.chemical_compound chemistry Internal medicine Emergency Medicine medicine Original Article Liver function business Multiple organ dysfunction syndrome Survival rate TBIL |
| Zdroj: | World Journal of Emergency Medicine. 5:214 |
| ISSN: | 1920-8642 |
| DOI: | 10.5847/wjem.j.issn.1920-8642.2014.03.010 |
| Popis: | BACKGROUND Acute liver failure (ALF) caused by viral and non-viral hepatitis is often accompanied with severe metabolic disorders, the accumulation of toxic substances and continuous release and accumulation of a large number of endogenous toxins and inflammatory mediators. The present study aimed to investigate the effects of various combined non-biological artificial liver treatments for patients with acute liver failure (ALF) complicated by multiple organ dysfunction syndrome (MODS). METHODS Thirty-one patients with mid- or late-stage liver failure complicated by MODS (score 4) were randomly divided into three treatment groups: plasmapheresis (PE) combined with hemoperfusion (HP) and continuous venovenous hemodiafiltration (CVVHDF), PE+CVVHDF, and HP+CVVHDF, respectively. Heart rate (HR) before and after treatment, mean arterial pressure (MAP), respiratory index (PaO2/FiO2), hepatic function, platelet count, and blood coagulation were determined. RESULTS Significant improvement was observed in HR, MAP, PaO2/FiO2, total bilirubin (TBIL) and alanine aminotransferase (ALT) levels after treatment (P |
| Databáze: | OpenAIRE |
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