Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
| Autor: | Michaelangelo P. Aoun, Wadih Naja |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.drug_class
Social anxiety Translational research Oxytocin Anxiolytic Anxiety Disorders 030227 psychiatry Clinical trial Translational Research Biomedical 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Clinical research Neuroimaging Oxytocics medicine Anxiety Humans medicine.symptom Psychology hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | Current psychiatry reports. 19(10) |
| ISSN: | 1535-1645 |
| Popis: | This review aims to evaluate the most recent literature examining the oxytocin (OXT) system’s role in human anxiety by surveying various fields of preclinical and clinical research supporting this role, and queries whether the OXT system might be a target for novel anxiolytics. Evidence from the diverse body of literature presented here, from translational research, genetic and neuroimaging studies, to clinical trials of intranasal (IN) OXT reveals a positive association. In addition, some moderators (e.g., sex, specificities to cues) of OXT’s anxiolytic effects can have an important influence on its outcomes, awaiting further research. Evidence for the role of OXT in regulating anxiety is undeniable. We expect that the diverse particularities of the OXT system will help broaden our understanding of anxiety and stress-related disorders. We conclude that OXT promises an enticing treatment option for human anxiety disorders especially those associated with socio-emotional dysfunctions. |
| Databáze: | OpenAIRE |
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