Novel resin-based dental material with anti-biofilm activity and improved mechanical property by incorporating hydrophilic cationic copolymer functionalized nanodiamond
Autor: | Xiaodong Xing, Yuhong Xiao, Weiwei Cao, Xi Wang, Yu Zhang, Peili Li, Lina Wang, Qiang Li, Zhiwen Ye |
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Rok vydání: | 2018 |
Předmět: |
Materials science
Cell Survival Polymers Biomedical Engineering Biophysics Nanoparticle Bioengineering 02 engineering and technology Mechanics Nanodiamonds Biomaterials Streptococcus mutans 03 medical and health sciences Dental Materials Mice 0302 clinical medicine stomatognathic system Flexural strength Copolymer Animals Nanodiamond Nanocomposite biology Flexural modulus 030206 dentistry 021001 nanoscience & nanotechnology biology.organism_classification RAW 264.7 Cells Chemical engineering Biofilms 0210 nano-technology Antibacterial activity |
Zdroj: | Journal of materials science. Materials in medicine. 29(11) |
ISSN: | 1573-4838 |
Popis: | There is an increasing clinical need to design dental restorative materials that combine excellent mechanical property and anti-biofilm activity. In the current study, photocurable polycation functionalized nanodiamond (QND) was synthesized and proposed as novel filler for dental resins. By reason of increased repulsive force between nanoparticles and enhanced compatibility with resin matrix, QND dispersed uniformly in reinforced resins, which would help to transfer stress and deformation from the matrix to fillers more efficiently, resulting in a significant improvement in mechanical properties. Notably, the Vickers’s hardness, flexural strength and flexural modulus of resins containing 1.0 wt% QND were 44.5, 36.1 and 41.3% higher than that of control, respectively. The antibacterial activity against Streptococcus mutans (S. mutans) showed that QND-incorporated resins produced anti-adhesive property due to their hydrophilic surfaces and could suppress bacterial growth as a result of the contact-killing effect of embedded nanocomposites. As the synergistic effect of anti-adhesive and bactericidal performance, resins loading 1.0~1.5 wt% QNDs displayed excellent anti-biofilm activity. Meanwhile, the results of macrophage cytotoxicity showed that the proliferation of RAW 264.7 cells remained 84.3%, even at a concentration of 1.0 wt% QNDs after 7-day incubation. Therefore, the QND-containing dental resin with the combination of high mechanical property, bacteria-repellent capability and antibacterial performance holds great potential as a restorative material based on this scheme. |
Databáze: | OpenAIRE |
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