Emergence of a Kwashiorkor-Like Syndrome Associated with Protein-Calorie Malnutrition in the Developing Rhesus Monkey (Macaca Mulatta)
| Autor: | Robert R. Zimmermann, Charles R. Geist, O. W. Smith, Enid M. Geist |
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| Rok vydání: | 1977 |
| Předmět: | |
| Zdroj: | Psychological Reports. 40:1339-1344 |
| ISSN: | 1558-691X 0033-2941 |
| DOI: | 10.2466/pr0.1977.40.3c.1339 |
| Popis: | An infant rhesus monkey was separated from its mother at 90 days of age, housed individually, and at 120 days of age placed on a purified low protein diet containing 3.5% casein by weight. To enhance the effects of protein-calorie malnutrition, a protein-deficient diet containing 2.0% casein by weight was introduced at 415 days of age. When compared with other animals on an identical dietary regime, the subject manifested a reduced intake of food and a marked decrease in weight gain. Clinical symptomatology analogous to human kwashiorkor progressively developed into an acute phase as a result of protein deficiency and included: brittle, depigmented, and sparse hair; chronic diarrhea; dermatitis as “flaky-paint rash” on the extremities and “moist groin rash;” edema of the face and extremities; hypoalbuminemia; hypoproteinemia; retardation of growth and physical development; and wasting of muscle tissue. Within 172 days following the dietary shift from 3.5% to 2.0% casein, a terminal state was evidenced. |
| Databáze: | OpenAIRE |
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