Toxicity Evaluation of Quantum Dots (ZnS and CdS) Singly and Combined in Zebrafish (Danio rerio)
| Autor: | Isabel M.P.L.V.O. Ferreira, Beatriz Matos, David Sousa, Marta Martins, Antonio Cid Samamed, Mário Diniz |
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| Přispěvatelé: | DQ - Departamento de Química, UCIBIO - Applied Molecular Biosciences Unit, DCEA - Departamento de Ciências e Engenharia do Ambiente, MARE - Centro de Ciências do Mar e do Ambiente, LAQV@REQUIMTE, CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N), DCM - Departamento de Ciência dos Materiais |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aquatic Organisms
Health Toxicology and Mutagenesis Danio lcsh:Medicine quantum dots 02 engineering and technology 010501 environmental sciences Sulfides medicine.disease_cause 01 natural sciences Article Superoxide dismutase Lipid peroxidation chemistry.chemical_compound SDG 3 - Good Health and Well-being medicine Cadmium Compounds Animals oxidative stress 0105 earth and related environmental sciences biology Dose-Response Relationship Drug Chemistry Superoxide Dismutase lcsh:R technology industry and agriculture Public Health Environmental and Occupational Health toxicity Glutathione 021001 nanoscience & nanotechnology biology.organism_classification equipment and supplies Catalase zebrafish CdS Oxidative Stress Biochemistry ZnS Zinc Compounds Toxicity biology.protein Freshwater fish Lipid Peroxidation 0210 nano-technology Oxidative stress |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP International Journal of Environmental Research and Public Health Volume 17 Issue 1 International Journal of Environmental Research and Public Health, Vol 17, Iss 1, p 232 (2019) |
| Popis: | The exponential growth of nanotechnology has led to the production of large quantities of nanomaterials for numerous industrial, technological, agricultural, environmental, food and many other applications. However, this huge production has raised growing concerns about the adverse effects that the release of these nanomaterials may have on the environment and on living organisms. Regarding the effects of QDs on aquatic organisms, existing data is scarce and often contradictory. Thus, more information is needed to understand the mechanisms associated with the potential toxicity of these nanomaterials in the aquatic environment. The toxicity of QDs (ZnS and CdS) was evaluated in the freshwater fish Danio rerio. The fishes were exposed for seven days to different concentrations of QDs (10, 100 and 1000 µ g/L) individually and combined. Oxidative stress enzymes (catalase, superoxide dismutase and glutathione S-transferase), lipid peroxidation, HSP70 and total ubiquitin were assessed. In general, results suggest low to moderate toxicity as shown by the increase in catalase activity and lipid peroxidation levels. The QDs (ZnS and CdS) appear to cause more adverse effects singly than when tested combined. However, LPO results suggest that exposure to CdS singly caused more oxidative stress in zebrafish than ZnS or when the two QDs were tested combined. Levels of Zn and Cd measured in fish tissues indicate that both elements were bioaccumulated by fish and the concentrations increased in tissues according to the concentrations tested. The increase in HSP70 measured in fish exposed to 100 µ g ZnS-QDs/L may be associated with high levels of Zn determined in fish tissues. No significant changes were detected for total ubiquitin. More experiments should be performed to fully understand the effects of QDs exposure to aquatic biota. |
| Databáze: | OpenAIRE |
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