Angiotensin peptides in brain and pituitary of rat and sheep
| Autor: | Anne C. Lawrence, Duncan J. Campbell, Lain J. Clarke |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pituitary gland
medicine.medical_specialty Endocrine and Autonomic Systems Endocrinology Diabetes and Metabolism Neuropeptide Angiotensin-converting enzyme Biology Peptide hormone Angiotensin II Cellular and Molecular Neuroscience Endocrinology medicine.anatomical_structure Hypothalamus Median eminence Internal medicine Cerebellar cortex cardiovascular system medicine biology.protein hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of neuroendocrinology. 4(2) |
| ISSN: | 0953-8194 |
| Popis: | Several lines of evidence indicate that angiotensin peptides may be formed in the brain, where angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) may function as neurotransmitters. However, there is considerable controversy concerning the identity and levels of angiotensin peptides in the brain. We have used a novel high performance liquid chromatography-based radioimmunoassay to measure Ang-(1-7), Ang II, Ang-(1-9) and Ang I in various brain regions and in the pituitary of the rat and sheep. We also studied the effect of different methods of tissue extraction, and the effect of the converting enzyme inhibitor ramipril, on angiotensin peptide levels in the rat hypothalamus. The levels of Ang-(1-7), Ang II, Ang-(1-9) and Ang I were low ( |
| Databáze: | OpenAIRE |
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