Right ventricular pressure overload alters cardiac lipid composition

Autor: M. van Weeghel, Beatrijs Bartelds, Frédéric M. Vaz, Rolf M. F. Berger, Quint A. J. Hagdorn, Anne-Marie C. Koop, A. Gerding, T. van Leusden, Debby P.Y. Koonen, Herman H W Silljé, Guido P. L. Bossers
Přispěvatelé: Cardiovascular Centre (CVC), Center for Liver, Digestive and Metabolic Diseases (CLDM), Vascular Ageing Programme (VAP), Laboratory Genetic Metabolic Diseases, AGEM - Inborn errors of metabolism, APH - Personalized Medicine, APH - Methodology, ACS - Diabetes & metabolism
Rok vydání: 2019
Předmět:
Male
Heart disease
Ventricular Dysfunction
Right
ENERGY-METABOLISM
Hemodynamics
030204 cardiovascular system & hematology
medicine.disease_cause
chemistry.chemical_compound
0302 clinical medicine
TETRALINOLEOYL-CARDIOLIPIN
Cardiolipin
FATTY-ACID UPTAKE
030212 general & internal medicine
Right ventricular dysfunction
OXIDATIVE STRESS
Beta oxidation
Ventricular Remodeling
Ventricular pressure
Cardiology
HEART-FAILURE
Cardiology and Cardiovascular Medicine
COMPLEX I DYSFUNCTION
PULMONARY ARTERIAL-HYPERTENSION
medicine.medical_specialty
MITOCHONDRIAL DYSFUNCTION
Diglyceride
Heart Ventricles
03 medical and health sciences
Internal medicine
Ventricular Pressure
medicine
Animals
Rats
Wistar
METABOLIC MODULATION
business.industry
Myocardium
Hypertrophy
Lipid Metabolism
medicine.disease
PERFORMANCE LIQUID-CHROMATOGRAPHY
Pulmonary hypertension
Rats
Disease Models
Animal
Metabolism
chemistry
Heart failure
Ventricular Function
Right
business
Oxidative stress
Zdroj: International Journal of Cardiology, 287, 96-105. ELSEVIER IRELAND LTD
International journal of cardiology, 287, 96-105. Elsevier Ireland Ltd
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2019.04.004
Popis: Introduction: Right ventricular (RV) failure due to pressure load is an important determinant of clinical outcome in pulmonary hypertension, congenital heart disease and left ventricular failure. The last decades it has become clear that metabolic dysregulation is associated with the development of RV-failure. However, underlying mechanisms remain to be unraveled. Recently, disruption of intracardiac lipid content has been suggested as potential inducer of RV failure. In the present study, we used a rat model of RV-dysfunction and aimed to obtain insight in temporal changes in RV-function, -remodelling and -metabolism and relate this to RV lipid content.Methods and results: Male Wistar WU rats were subjected to pulmonary artery banding (n=25) or sham surgery (n=14) and cellular, hemodynamic and metabolic assessments took place after 2, 5 and 12 weeks. In this model RV dysfunction and remodelling occurred, including early upregulation of oxidative stress markers. After 12 weeks of pressure load, lipidomics revealed significant decreases of myocardial diglycerides and cardiolipins, driven by (poly-) unsaturated forms. The decrease of cardiolipins was driven by its most abundant form, tetralinoleoylcardiolipin. Mitochondrial capacity for fatty acid oxidation preserved, while the capacity for glucose oxidation increased.Conclusion: RV dysfunction due to pressure load, is associatedwith decreased intracardiac unsaturated lipids, especially tetralinoleoylcardiolipin. This was accompanied with preserved mitochondrial capacity regarding fatty acids oxidation, with increased capacity for glucose oxidation, and early activation of oxidative stress. We suggest that early interventions should be directed towards preservation of lipid availability as possible mean in order to prevent RV failure. (c) 2019 Published by Elsevier B.V.
Databáze: OpenAIRE
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