Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis
| Autor: | Hisashi Sugiura, Kiichiro Danno, Yusuke Hirota, Mitsuyoshi Omoto, Masami Uehara |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Keratinocytes Allergy Pathology medicine.medical_specialty Adolescent Substance P Dermatology Dermatitis Atopic Basal (phylogenetics) chemistry.chemical_compound Nerve Fibers Prurigo Reference Values medicine Humans Peripheral Nerves Skin Nerve Endings business.industry General Medicine Atopic dermatitis medicine.disease Immunohistochemistry Peripheral Microscopy Electron chemistry Thiolester Hydrolases business Free nerve ending Ubiquitin Thiolesterase |
| Zdroj: | Archives of dermatological research. 289(3) |
| ISSN: | 0340-3696 |
| Popis: | The density and fine structure of the peripheral nerve system in various skin lesions of 64 patients with atopic dermatitis (AD) was quantitatively analyzed by immunohistochemical staining with antibodies directed against protein gene product (PGP) and substance P (SP). The density of PGP-positive peripheral nerves was 2.5 x 10(3) microns2/delta s (delta s = 0.24 mm2 selected area) in early acute lesions, 3.8 x 10(3) microns2/delta s in subacute lesions, 4.9 x 10(3) microns2/delta s in lichenified lesions and 7.1 x 10(3) microns2/delta s in prurigo lesions of AD. The density of nerve fibers in subacute, lichenified and prurigo lesions was significantly higher than in uninvolved skin of AD patients (2.0 x 10(3) microns2/delta s). Electron microscopically, bulging of axons with many mitochondria and a loss of their surrounding sheath of Schwann cells suggests that the free nerve endings in skin lesions of AD are in an active state of excitation. Many pinocytotic vesicles in the periphery of basal keratinocytes facing nerve endings which contained many neurovesicles suggests reciprocal effects between keratinocytes and nerve endings. The number of SP-positive nerve fibers in AD lesions was far less than one-tenth of the number of PGP-positive nerve fibers. |
| Databáze: | OpenAIRE |
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