Impaired Memory Awareness and Loss Integration in Self-Referential Network Across the Progression of Alzheimer’s Disease Spectrum
Autor: | Wenwen Xu, Guanjie Hu, Chen Xue, Honglin Ge, Jiu Chen, Wenzhang Qi, Xingjian Lin, Shanshan Chen, Yu Song, Ju Gao |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Memory Episodic Audiology 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Neuroimaging Alzheimer Disease medicine Humans Cognitive Dysfunction 0501 psychology and cognitive sciences Cognitive decline Correlation test Episodic memory Aged Memory Disorders business.industry General Neuroscience Anosognosia 05 social sciences Disease spectrum Brain General Medicine Awareness Impaired memory medicine.disease Psychiatry and Mental health Clinical Psychology Agnosia Female Amnesia Disconnection Nerve Net Geriatrics and Gerontology business 030217 neurology & neurosurgery |
Zdroj: | Journal of Alzheimer's Disease. 83:111-126 |
ISSN: | 1875-8908 1387-2877 |
Popis: | Background: Anosognosia, or unawareness of memory deficits, is a common manifestation of Alzheimer’s disease (AD), but greatly variable in subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) subjects. Self-referential network (SRN) is responsible for self-referential processing and considered to be related to AD progression. Objective: Our aim is to explore connectivity changes of SRN and its interaction with memory-related network and primary sensorimotor network (SMN) in the AD spectrum. Methods: About 444 Alzheimer’s Disease Neuroimaging Initiative subjects (86 cognitively normal [CN]; 156 SCD; 146 aMCI; 56 AD) were enrolled in our study. The independent component analysis (ICA) method was used to extract the SRN, SMN, and memory-related network from all subjects. The alteration of functional connectivity (FC) within SRN and its connectivity with memory-related network/SMN were compared among four groups and further correlation analysis between altered FC and memory awareness index as well as episodic memory score were performed. Results: Compared with CN group, individuals with SCD exhibited hyperconnectivity within SRN, while aMCI and AD patients showed hypoconnectivity. Furthermore, aMCI patients and AD patients both showed the interruption of the FC between the SRN and memory-related network compared to CN group. Pearson correlation analysis showed that disruptive FC within SRN and its interaction with memory-related network were related to memory awareness index and episodic memory scores. Conclusion: In conclusion, impaired memory awareness and episodic memory in the AD spectrum are correlated to the disconnection within SRN and its interaction with memory-related network. |
Databáze: | OpenAIRE |
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