Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study
| Autor: | Shinichiro Uehara, Mikiko Shibata, Hideo Koh, Tomoshige Hayashi, Keiko Oue, Kyoko Kogawa Sato, Michio Morimoto, Hiroshi Kambe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Renal function 030209 endocrinology & metabolism urologic and male genital diseases Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Internal medicine Diabetes mellitus Humans Medicine Clinical Epidemiology Prospective Studies 030212 general & internal medicine Renal Insufficiency Chronic Risk factor Prospective cohort study Aged Proportional Hazards Models prospective cohort study lcsh:R5-920 Proteinuria business.industry Incidence Hazard ratio General Medicine Middle Aged medicine.disease Quartile Original Article Female epidemiology medicine.symptom proteinuria business lcsh:Medicine (General) gamma-glutamyltransferase chronic kidney disease Glomerular Filtration Rate Kidney disease |
| Zdroj: | Journal of Epidemiology, Vol 30, Iss 4, Pp 163-169 (2020) Journal of Epidemiology |
| ISSN: | 1349-9092 0917-5040 |
| Popis: | Background: Serum gamma-glutamyltransferase has been recognized as the risk factor of cardiovascular and metabolic diseases. However, the association between serum gamma-glutamyltransferase and the risk of chronic kidney disease is not well known, and no prospective studies have examined separately the relationship of serum gamma-glutamyltransferase with the risk of proteinuria versus that of low estimated glomerular filtration rate (eGFR). Methods: We prospectively followed 9,341 Japanese men who did not have low eGFR, proteinuria, or diabetes, and did not take antihypertensive medications at entry for the analysis of proteinuria, and we followed 9,299 men for the analysis of low eGFR. We defined “persistent proteinuria” as proteinuria detected two or more times consecutively and persistently as ≥1+ on urine dipstick at the annual check-up until the end of follow-up. Low eGFR was defined as eGFR |
| Databáze: | OpenAIRE |
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