Cell-mediated and humoral immune responses to chlamydial antigens in guinea pigs infected ocularly with the agent of guinea pig inclusion conjunctivitis
| Autor: | H B Ostler, H. Keshishyan, George Senyk, Daniel P. Stites, Ernest Jawetz, Lavelle Hanna, R. Kerlan, D J Schanzlin |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Freund's Adjuvant
Guinea Pigs Immunology Chlamydia trachomatis Lymphocyte Activation Tuberculin medicine.disease_cause Microbiology Guinea pig Immune system Antigen Immunity medicine Animals Macrophage Migration-Inhibitory Factors Skin Tests Chlamydia psittaci Antigens Bacterial Immunity Cellular biology Conjunctivitis Inclusion biology.organism_classification Antibodies Bacterial Infectious Diseases Freund's adjuvant Parasitology Macrophage migration inhibitory factor Research Article |
| Zdroj: | Infection and Immunity. 32:304-310 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.32.1.304-310.1981 |
| Popis: | Cell-mediated immune response and humoral response to chlamydial antigens were investigated in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis (GPIC). Pronounced cell-mediated immune response to the homologous antigen, as well as to two other chlamydial antigens, 6BC (Chlamydia psittaci) and LB-1 (C. trachomatis), occurred in all infected animals. Cell-mediated immune response to GPIC, and to a lesser extent to 6BC and LB-1 as well, was enhanced with time after infection even without the re-inoculation of the infectious agent. Extensive cross-reactions among the three chlamydial antigens during the cell-mediated immune response appeared to be due to shared species-specific and group-reactive antigens. Serum antibody response was pronounced and uniform to GPIC; it was less marked to 6BC and LB-1, with fewer cross-reactions than seen in tests for cell-mediated immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|