Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive rats
| Autor: | Charles T. Stier, C. Andrew Powers, Praveen N. Chander, Sreeharsha N. Masineni, Gagan D. Singh |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Aging End organ damage Urinary system Blood Pressure Kidney Severity of Illness Index Blood Urea Nitrogen Excretion Sex Factors Risk Factors Internal medicine Rats Inbred SHR Internal Medicine medicine Animals Telemetry Stroke Blood urea nitrogen Proteinuria business.industry Myocardium medicine.disease Rats Plethysmography Disease Models Animal Endocrinology Blood pressure Hypertension Disease Progression Kidney Failure Chronic Female medicine.symptom business Follow-Up Studies |
| Zdroj: | American journal of hypertension. 18(6) |
| ISSN: | 0895-7061 |
| Popis: | It is well-known that gender affects the progression of kidney failure. Male patients exhibit faster development of age-dependent renal disease than do women. In the present study, we examined arterial blood pressure (BP), proteinuria, and end-organ damage in male and female retired breeders from our colony of stroke-prone spontaneously hypertensive rats (SHRSP).Male (n = 7) and female (n = 11) SHRSP littermates maintained on Purina Laboratory Chow 5008 and water were studied starting at 53 weeks of age. Systolic BP was measured by tail-cuff plethysmography and 24-h urinary protein excretion was quantified while animals were housed in metabolic cages. Blood was obtained by retro-orbital bleeding. Mean arterial pressure (MAP) was then monitored by radiotelemetry. Organs were preserved for histopathologic assessment.Tail-cuff systolic BP did not differ between the sexes. Male SHRSP exhibited greater proteinuria (128 +/- 7 mg/d) than females (21 +/- 5 mg/d, P.001). Blood urea nitrogen was higher in males (22 +/- 2 mg%) v females (15 +/- 1 mg%, P.005). The MAP by radiotelemetry did not differ between the sexes (179 +/- 3 mm Hg in males v 192 +/- 6 mm Hg in females, 2 weeks after probe implantation). Stroke-related mortality was greater in males (83%) than females (10%). Renal vascular disease including thrombotic microangiopathy affecting glomeruli and microvessels and cardiac damage were more prominent in male SHRSP.These findings demonstrate that male gender is a major risk factor for multisystem end-organ damage associated with aging and hypertension in SHRSP, despite comparable degrees of hypertension among males and females. |
| Databáze: | OpenAIRE |
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