Whole-body protein turnover in malnourished patients with child class B and C cirrhosis on diets low to high in protein energy
| Autor: | M. H. Bicudo, Roberto Carlos Burini, Regiane Maio, T. A. Rezende, Camila Renata Corrêa, Isaias Dichi, Jane Bandeira Dichi, Aparecida Y.O. Angeleli |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Nitrogen balance Cirrhosis Nitrogen Endocrinology Diabetes and Metabolism Protein metabolism Glycine Biology chemistry.chemical_compound Ammonia Liver Cirrhosis Alcoholic Internal medicine medicine Humans Nutrition and Dietetics Nitrogen Isotopes Protein turnover Case-control study Proteins Metabolism Fasting Middle Aged medicine.disease Nutrition Disorders Protein catabolism Endocrinology chemistry Case-Control Studies Lean body mass Dietary Proteins Energy Intake |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 17(3) |
| ISSN: | 0899-9007 |
| Popis: | The purpose of this study was to determine the rate of whole-body protein turnover in moderately and severely alcoholic, malnourished, cirrhotic patients fed with different amounts of protein or energy. Six male patients (Child classes B and C) and four age- and sex-matched healthy control subjects were studied for 18 d in fasting and feeding states; a single oral dose of [(15)N]glycine was used as a tracer and urinary ammonia was the end product. The kinetic study showed that patients had higher protein catabolism while fasting (patients: 3.14 +/- 1.2 g of lean body mass/9 h; controls: 1.8 +/- 0.3 g of lean body mass/9 h; P < 0.02). Although not statistically significant, protein catabolism (grams of lean body mass/9 h) was lower with the hyperproteic/hyperenergetic diet when compared with fasting. Nitrogen retention was consistent with the lower protein-catabolism rate; a statistically significant increase in nitrogen balance was observed when patients were fed with the hyperproteic/hyperenergetic diet compared with fasting (4.3 +/- 3.2 g of nitrogen/d and -2.2 +/- 1.9 g of nitrogen/d, respectively; P < 0.01). These data indicate that Child class B and C cirrhotic patients are hypercatabolic and that long-term nutritional intervention with a hyperproteic/hyperenergetic diet is likely needed to improve their clinical and nutritional status. |
| Databáze: | OpenAIRE |
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