The race to discover the insect vector of kala-azar: a great saga of tropical medicine 1903–1942
| Autor: | R. Killick-Kendrick |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Veterinary medicine
medicine.medical_specialty Antiprotozoal Agents Leishmania donovani India Pathology and Forensic Medicine Race (biology) Tropical Medicine Organometallic Compounds medicine Animals Humans Urea biology Phlebotomus argentipes Transmission (medicine) Insect Bites and Stings History 20th Century biology.organism_classification medicine.disease Nontherapeutic Human Experimentation Insect Vectors Visceral leishmaniasis Phlebotomus Vector (epidemiology) Tropical medicine Leishmaniasis Visceral Ethnology |
| Zdroj: | Bulletin de la Société de pathologie exotique. 106:131-137 |
| ISSN: | 1961-9049 0037-9085 |
| Popis: | In the 19(th) century, a devastating epidemic of visceral leishmaniasis (kala-azar) swept through northeast India. After identification of the pathogenic agent, Leishmania donovani, in 1903, the question of its transmission remained to be resolved. In 1904, thanks to work by L. Rogers on cultures of this parasite it became probable that a haematophagous arthropod was responsible for transmission. J.A. Sinton suggested, in 1925, the distribution of the sand fly Phlebotomus argentipes was similar to that of the disease and, thereafter, two independent teams led by H.E. Shortt in Assam and R. Knowles and L. Napier in Calcutta concentrated on this potential vector. Parallel work was in progress in China, directed by E. Hindle and W. S. Patton for the Royal Society Kala-azar Commission, on another species of sand fly. In 1942 the Assam workers transmitted L. donovani to five human volunteers by the bites of colonised P. argentipes and the race was over. |
| Databáze: | OpenAIRE |
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