Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections
| Autor: | E. A. Nokel, O. V. Kotel’nikova, V. S. Zueva, A. P. Alliluev, Marina Tokarskaya, Natalia Yastrebova, Lev D. Rumsh, O. A. Razgulyaeva, E. I. Gordeeva, T. D. Melikhova, E. N. Kaliberda, L. S. Zhigis, Yuri Prokopenko, A. A. Zinchenko |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cross Protection 030106 microbiology Immunology Meningococcal Vaccines chemical and pharmacologic phenomena Meningococcal vaccine Neisseria meningitidis medicine.disease_cause Microbiology Pneumococcal Infections Epitope 03 medical and health sciences fluids and secretions stomatognathic system Streptococcus pneumoniae medicine Animals Mice Inbred BALB C Vaccines Synthetic biology Streptococcus Immune Sera Serine Endopeptidases medicine.disease Antibodies Bacterial Recombinant Proteins Meningococcal Infections Pneumococcal infections 030104 developmental biology Infectious Diseases Immunization biology.protein Female Rabbits Antibody |
| Zdroj: | Microbes and Infection. 21:336-340 |
| ISSN: | 1286-4579 |
| Popis: | Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from N. meningitidis serogroup B were detected. Thus, the cross-reactive protection against meningococcal and pneumococcal infections has been demonstrated in vivo. Presumably it indicates the presence of common epitopes in the N. meningitidis IgA1 protease and S. pneumoniae surface proteins. |
| Databáze: | OpenAIRE |
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