Increased blood pressure and aortic stiffness among abusers of anabolic androgenic steroids: potential effect of suppressed natriuretic peptides in plasma?
| Autor: | Caroline Kistorp, Marie Lindhardt Johansen, Morten Schou, Finn Gustafsson, Per Lav Madsen, Peter S. Ulriksen, Christian Selmer, Jens Faber, Jon J Rasmussen, Peter Hovind |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Systolic hypertension medicine.drug_class Substance-Related Disorders Blood Pressure 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Copeptin Vascular Stiffness medicine.artery Internal medicine Internal Medicine medicine Natriuretic peptide Humans 030212 general & internal medicine Natriuretic Peptides Testosterone Congeners Aorta Aldosterone business.industry Blood Pressure Determination Resistance Training Middle Aged medicine.disease Blood pressure Endocrinology Cross-Sectional Studies chemistry Case-Control Studies Hypertension Arterial stiffness Aortic stiffness Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of hypertension. 36(2) |
| ISSN: | 1473-5598 |
| Popis: | BACKGROUND Abuse of anabolic androgenic steroids (AAS) is prevalent among recreational athletes and adverse effects on blood pressure (BP) and arterial stiffness could be substantial. Testosterone decreases natriuretic peptides which are key components in BP-regulation and may impair BP-homeostasis in AAS abusers. OBJECTIVE To investigate BP and aortic stiffness in relation to natriuretic peptides among current AAS abusers, former AAS abusers and controls. METHODS In this cross-sectional study, 37 current AAS abusers, 33 former AAS abusers and 30 controls were included. All participants were men involved in recreational strength training. We used 24-h BP monitoring, assessed proximal aorta distensibility index (ADI) by MRI and obtained overnight fasting blood samples to measure: midregional proatrial natriuretic peptide (MR-proANP), aldosterone, noradrenaline and copeptin. RESULTS Current AAS abusers exhibited higher mean (95% confidence interval) 24-h systolic BP than controls [132 (129; 135) versus 124 (120; 128) mmHg, P = 0.005] and systolic hypertension was more frequent among current AAS abusers than controls (51 versus 17%, P = 0.009). ADI was lower among both current and former AAS abusers suggesting higher aortic stiffness; %-difference (95% confidence interval) from controls: -21% (-35; -5) and -21% (-36; -4), P |
| Databáze: | OpenAIRE |
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