Efficacy of Edaravone, a Free Radical Scavenger, on Left Ventricular Function and Structure in Diabetes Mellitus
| Autor: | Tetsuya Hayashi, Koichi Sohmiya, Sakiko Inamoto, Tatsuhiko Mori, Yasushi Kitaura, Hiroshi Mori, Yoshikatsu Okada, Nobuaki Okuda |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Male Cardiac function curve medicine.medical_specialty Rats Inbred OLETF Blotting Western Nitric Oxide Synthase Type II Hemodynamics Blood sugar medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Ventricular Function Left chemistry.chemical_compound Diabetes mellitus Internal medicine Edaravone medicine TBARS Animals Pharmacology Superoxide Dismutase Myocardium Free Radical Scavengers Free radical scavenger medicine.disease Immunohistochemistry Rats Microscopy Electron Endocrinology Diabetes Mellitus Type 2 chemistry Microscopy Polarization Nitric Oxide Synthase Cardiology and Cardiovascular Medicine Antipyrine NADP Oxidative stress |
| Zdroj: | Journal of Cardiovascular Pharmacology. 41:923-929 |
| ISSN: | 0160-2446 |
| Popis: | This study was designed to assess the efficacy of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger that possesses anti-oxidant effects, on cardiac function and fine structure of the left ventricular myocardium in diabetes mellitus. Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of spontaneous development of type II diabetes (30 weeks; n = 15) were divided into two groups and treated with edaravone 30 mg/kg/d or vehicle for 2 weeks. OLETF rats showed hyperglycemia (352 +/- 71 mg/dl vs normal control; 128 +/- 52 mg/dl), increased thiobarbituric acid-reactive substances (TBARS; 6.9 +/- 2.5 nM/ml vs 2.8 +/- 0.6 nM/ml), and decreased superoxide dismutase activity (21.5 +/- 0.9 U/ml vs 25.8 +/- 0.7 U/ml). Increased left ventricular end-diastolic pressure (12 +/- 3 mm Hg vs 6 +/- 2 mm Hg) and hypertrophied cardiocytes (23.1 +/- 1.4 vs 17.6 +/- 1.0 microm) were also observed (P < 0.05, respectively). Edaravone could not improve plasma glucose level and hemodynamic parameters but significantly decreased TBARS values (3.8 +/- 0.5) and increased superoxide dismutase activity (24.5 +/- 0.8) (vs OLETF, P < 0.05, respectively). Moreover, edaravone effectively preserved cardiocyte diameter (18.2 +/- 0.9 microm) and the fine structure of mitochondria. Thus, edaravone exhibits modest cardiac protection in diabetes mellitus independent of blood sugar level. |
| Databáze: | OpenAIRE |
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