Glutathione S-transferases deletions may act as prognosis and therapeutic markers in breast cancer

Autor: Roberta Losi Guembarovski, Flávia Luísa Dias, Tânia Longo Mazzuco, Carlos Hiroji Hiroki, Maria Angelica Ehara Watanabe, Clodoaldo Zago Campos, Glauco Akelinghton Freire Vitiello, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin Hirata
Rok vydání: 2017
Předmět:
Zdroj: Clinical and Experimental Medicine. 18:27-35
ISSN: 1591-9528
1591-8890
DOI: 10.1007/s10238-017-0461-6
Popis: Breast cancer (BC) is the main worldwide neoplasia in women. The metabolic balance between xenobiotic absorption and elimination rates plays an important role in preventing DNA damage and, consequently, tumor development. The glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the NAD(P)H quinone oxidoreductase are important enzymes involved in phase II detoxification reactions. Deletions in GSTM1 and GSTT1, and single-nucleotide polymorphism (SNP) in NQO1 (rs1800655) have been investigated in cancer context, revealing conflicting results. The present study analyzed these genetic polymorphisms in 121 BC patients and 151 BC-free controls in order to verify if they could act as susceptibility modifiers and/or prognostic factors. Binary logistic regressions adjusted by age were performed to assess associations between allelic variants and interactions in polymorphisms combination with BC susceptibility, but no significant association was found. Genotypes distribution was also compared between BC subtypes, but no significant difference was observed (p > 0.05). GSTM1 deletion was significantly associated with histopathological grade, with a greater proportion of patients presenting grade III tumors (p = 0.007). Univariate analysis identified tumor size as the only clinicopathological parameter potentially associated with recurrence risk in patients that received adjuvant chemotherapy (p
Databáze: OpenAIRE
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