Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
| Autor: | Ken Hadlock, Jeremy Reis, Ron Gascon, Rongzhen Zhang, Xia Jin, Deborah F. Gelinas, Robert G. Miller, Michael S. McGrath, Jason Mass, Amy Narvaez |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_treatment Immunology Disease Lymphocyte Activation Severity of Illness Index Immunologic activation Immune system parasitic diseases Immunology and Allergy Medicine Humans Amyotrophic lateral sclerosis Aged Aged 80 and over Immunosuppression Therapy biology business.industry Monocyte Amyotrophic Lateral Sclerosis Immunosuppression Macrophage Activation Middle Aged Spinal cord medicine.disease medicine.anatomical_structure Cross-Sectional Studies Neurology Immunoglobulin M Immune System Immunoglobulin G biology.protein Disease Progression Female Neurology (clinical) Antibody business |
| Zdroj: | Journal of neuroimmunology. 159(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS. |
| Databáze: | OpenAIRE |
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