Modeling and Optimization of Gas Sparging-Assisted Bacterial Cultivation Broth Microfiltration by Response Surface Methodology and Genetic Algorithm
| Autor: | Nataša Lj. Lukić, Vanja Vlajkov, Aleksandar Jokić, Ivana Pajčin, Arpad Kiralj, Jovana Grahovac, Selena Dmitrović |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
gas sparging Microfiltration Biomass Flux microbial biopesticide Filtration and Separation TP1-1185 Article response surface methodology Chemical engineering Bacillus velezensis genetic algorithm Chemical Engineering (miscellaneous) Response surface methodology Sparging Downstream processing Chemical technology Process Chemistry and Technology Membrane fouling microfiltration Pulp and paper industry specific energy consumption permeate flux desirability function TP155-156 Air sparging |
| Zdroj: | Membranes Volume 11 Issue 9 Membranes, Vol 11, Iss 681, p 681 (2021) |
| ISSN: | 2077-0375 |
| DOI: | 10.3390/membranes11090681 |
| Popis: | Production of highly efficient biomass-based microbial biopesticides significantly depends on downstream processing in terms of obtaining as high concentration of viable cells as possible. Microfiltration is one of the recommended operations for microbial biomass separation, but its main limitation is permeate flux decrease due to the membrane fouling. The effect of air sparging as a hydrodynamic technique for improvement of permeate flux during microfiltration of Bacillus velezensis cultivation broth was investigated. Modeling of the microfiltration was performed using the response surface methodology, while desirability function approach and genetic algorithm were applied for optimization, i.e., maximization of permeate flux and minimization of specific energy consumption. The results have revealed antagonistic relationship between the investigated dependent variables. The optimized values of superficial feed velocity and transmembrane pressure were close to the mean values of the investigated value ranges (0.68 bar and 0.96 m/s, respectively), while the optimized value of superficial air velocity had a more narrow distribution around 0.25 m/s. The results of this study have revealed a significant improvement of microfiltration performance by applying air sparging, thus this flux improvement method should be further investigated in downstream processing of different bacterial cultivation broths. |
| Databáze: | OpenAIRE |
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