Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis
| Autor: | Tiziana Granata, G. Zardini, Renato Mantegazza, P. Confalonieri, Carlo Antozzi, Roberto Spreafico, N. Aurisano, G. Airaghi |
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| Rok vydání: | 1998 |
| Předmět: |
Rasmussen's encephalitis
Adolescent Immunology Epilepsia Partialis Continua Neuropsychological Tests Receptors Metabotropic Glutamate Immunoglobulin G Central nervous system disease Epilepsy medicine Immunology and Allergy Humans Immunoadsorption Staphylococcal Protein A Autoantibodies Language biology business.industry Glutamate receptor medicine.disease Term (time) Neurology biology.protein Encephalitis Female Neurology (clinical) Antibody business Immunosorbents |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0028-3878 |
| Popis: | We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen9s encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases. |
| Databáze: | OpenAIRE |
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