SARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases
| Autor: | Mariana Matus, Peter R. Chai, Newsha Ghaeli, Timothy B. Erickson, Richard Bonneau, Amy Xiao, Xiaoqiong Gu, Mauricio Santillana, Katya Moniz, Steven F Rhode, Katelyn Foppe, Shijie Zhao, William P. Hanage, Kyle A. McElroy, Janelle R. Thompson, Fuqing Wu, Wei Lin Lee, Joshua A. Tucker, Mary Bushman, Katherine H. Huang, Noriko Endo, Federica Armas, Jonathan Nagler, Eric J. Alm, Jianbo Zhang, Megan A. Brown, Claire Duvallet, Stefan Wuertz |
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| Rok vydání: | 2022 |
| Předmět: |
Environmental Engineering
Coronavirus disease 2019 (COVID-19) viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Wastewater Article Humans Environmental Chemistry Medicine Symptom onset Viral shedding Waste Management and Disposal SARS-CoV-2 business.industry COVID-19 Pollution Virus Shedding Clinical diagnosis Immunology Longitudinal RNA Viral Foreshadow business Convolution model Viral load Disease transmission Wastewater surveillance |
| Zdroj: | The Science of the Total Environment |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2021.150121 |
| Popis: | Current estimates of COVID-19 prevalence are largely based on symptomatic, clinically diagnosed cases. The existence of a large number of undiagnosed infections hampers population-wide investigation of viral circulation. Here, we quantify the SARS-CoV-2 concentration and track its dynamics in wastewater at a major urban wastewater treatment facility in Massachusetts, between early January and May 2020. SARS-CoV-2 was first detected in wastewater on March 3. SARS-CoV-2 RNA concentrations in wastewater correlated with clinically diagnosed new COVID-19 cases, with the trends appearing 4–10 days earlier in wastewater than in clinical data. We inferred viral shedding dynamics by modeling wastewater viral load as a convolution of back-dated new clinical cases with the average population-level viral shedding function. The inferred viral shedding function showed an early peak, likely before symptom onset and clinical diagnosis, consistent with emerging clinical and experimental evidence. This finding suggests that SARS-CoV-2 concentrations in wastewater may be primarily driven by viral shedding early in infection. This work shows that longitudinal wastewater analysis can be used to identify trends in disease transmission in advance of clinical case reporting, and infer early viral shedding dynamics for newly infected individuals, which are difficult to capture in clinical investigations. Graphical abstract Unlabelled Image |
| Databáze: | OpenAIRE |
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