Tooth dentin defects reflect genetic disorders affecting bone mineralization
| Autor: | Catherine Chaussain, Claire Bardet, Céline Gaucher, Peter S. N. Rowe, S. Opsahl Vital, Anne George, Agnès Linglart |
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| Rok vydání: | 2012 |
| Předmět: |
Histology
Physiology Endocrinology Diabetes and Metabolism Dentistry Bone and Bones Article Extracellular matrix Calcification Physiologic stomatognathic system Deciduous teeth medicine Dentin Humans Chemistry business.industry Genetic Diseases Inborn medicine.disease Cell biology Radiography stomatognathic diseases Hypophosphatemic Rickets medicine.anatomical_structure Odontoblast Osteogenesis imperfecta Dentin mineralization business Tooth Calcification |
| Zdroj: | Bone. 50:989-997 |
| ISSN: | 8756-3282 |
| Popis: | Several genetic disorders affecting bone mineralization may manifest during dentin mineralization. Dentin and bone are similar in several aspects, especially pertaining to the composition of the extracellular matrix (ECM) which is secreted by well-differentiated odontoblasts and osteoblasts, respectively. However, unlike bone, dentin is not remodelled and is not involved in the regulation of calcium and phosphate metabolism. In contrast to bone, teeth are accessible tissues with the shedding of deciduous teeth and the extractions of premolars and third molars for orthodontic treatment. The feasibility of obtaining dentin makes this a good model to study biomineralization in physiological and pathological conditions. In this review, we focus on two genetic diseases that disrupt both bone and dentin mineralization. Hypophosphatemic rickets is related to abnormal secretory proteins involved in the ECM organization of both bone and dentin, as well as in the calcium and phosphate metabolism. Osteogenesis imperfecta affects proteins involved in the local organization of the ECM. In addition, dentin examination permits evaluation of the effects of the systemic treatment prescribed to hypophosphatemic patients during growth. In conclusion, dentin constitutes a valuable tool for better understanding of the pathological processes affecting biomineralization. |
| Databáze: | OpenAIRE |
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