Disease flare at prior pregnancy and disease activity at conception are important determinants of disease relapse at subsequent pregnancy in women with inflammatory bowel diseases
| Autor: | Amihai Rottenstreich, Benjamin Koslowsky, Eran Goldin, Sorina Grisaru Granovsky, Ariella Bar-Gil Shitrit, Shira Fridman Lev, Reut Rotem, Tali Mishael |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Multivariate analysis Birth weight Disease 03 medical and health sciences 0302 clinical medicine Pregnancy Recurrence Medicine Humans Prospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics Pregnancy Outcome Obstetrics and Gynecology General Medicine Odds ratio medicine.disease Inflammatory Bowel Diseases Symptom Flare Up Ulcerative colitis Pregnancy Complications 030220 oncology & carcinogenesis Cohort Gestation Female business |
| Zdroj: | Archives of gynecology and obstetrics. 301(6) |
| ISSN: | 1432-0711 |
| Popis: | Disease flare throughout gestation are not uncommon among women with inflammatory bowel diseases (IBD), and can substantially affect pregnancy outcomes. We aimed to evaluate the effect of prior pregnancy outcome on the risk of disease flare at subsequent pregnancy in women with IBD. Women with IBD attending a multidisciplinary clinic for the preconception, antenatal and postnatal treatment were prospectively recruited during 2011–2018. Overall, 476 IBD women were followed during the study period. Of them, 69 (14.5%) had two pregnancies throughout follow-up period and constituted the study cohort. Among these 69 women, 48 (69.6%) had Crohn's disease and 21 (30.4%) ulcerative colitis. The median interpregnancy interval was 20 [11–32] months. Overall, 34 (49.3%) women experienced disease flare at the subsequent pregnancy. In multivariate analysis, active disease at conception (odds ratio [95% CI]: 25.65 (3.05, 25.52), P |
| Databáze: | OpenAIRE |
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