Oxcarbazepine monotherapy in postherpetic neuralgia unresponsive to carbamazepine and gabapentin
| Autor: | A. Brogi, S. Lippi, C. Auletta, F. Brogi, S. Criscuolo |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cyclohexanecarboxylic Acids Gabapentin medicine.medical_treatment Drug Resistance Oxcarbazepine Pain Herpes Zoster medicine Humans Amines gamma-Aminobutyric Acid Aged Aged 80 and over business.industry Postherpetic neuralgia General Medicine Carbamazepine Middle Aged medicine.disease Treatment Outcome Anticonvulsant Neurology Tolerability Patient Satisfaction Anesthesia Neuropathic pain Quality of Life Neuralgia Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica. 111:229-232 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.2005.00300.x |
| Popis: | Objectives – We present the results of a preliminary, open-label trial to evaluate the efficacy and tolerability of oxcarbazepine in postherpetic neuralgia (PHN) unresponsive to treatment with antiepileptic drugs (carbamazepine and gabapentin) and local anesthetic blocks. Materials and methods – Twenty-four patients were treated with oxcarbazepine monotherapy for 8 weeks. Starting dose was 150 mg/day, subsequently increased by 150 mg/day every 2 days until a maintenance dose of 900 mg/day. Pain was assessed using a visual analog scale (VAS). Results – There was a significant decrease in the mean VAS score following 8 weeks of treatment (Δ = 5.33; pairedt-test: P |
| Databáze: | OpenAIRE |
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