Splenic Platelet Kinetics and Platelet Production after Major Reconstructive Vascular Surgery
| Autor: | Hans Wadenvik, Jack Kutti, Bo Risberg, Per Örtenwall |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Cell Survival Spleen Scintigraphy Internal medicine medicine.artery Platelet production Internal Medicine medicine Humans Platelet Aorta Abdominal Mean platelet volume Radionuclide Imaging Aged Aorta medicine.diagnostic_test Platelet Count business.industry Cell Cycle Indium Radioisotopes Middle Aged Vascular surgery Blood Vessel Prosthesis Surgery medicine.anatomical_structure Cardiology Female business Artery |
| Zdroj: | Acta Medica Scandinavica. 223:147-152 |
| ISSN: | 0001-6101 |
| Popis: | By using 111In-labelled platelets and dynamic gamma camera scintigraphy, platelet production rate and intrasplenic platelet kinetics were determined in 13 patients at 1 and 4 months after aortic reconstructive vascular surgery with implantation of dacron prostheses. A significant decrease in platelet production rate and venous platelet count was recorded over time after surgery. Irrespective of whether the exchangeable splenic platelet pool was estimated from initial recovery of platelet-bound radioactivity or from compartmental analysis, the size of this pool was significantly lower at the first study; a change in intrasplenic platelet transit time accounted for the observed difference. Platelet mean life-span increased over time after surgery but the difference between the duplicate studies was not statistically significant. It can be concluded that there is a reduction of platelet production rate and venous platelet count over time after major reconstructive vascular surgery. The early postoperative elevation in the platelet count is mainly the result of an increased platelet production and to a lesser degree due to redistribution of platelets between the splenic platelet pool and general circulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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