Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
| Autor: | Colm E. Nestor, Torbjörn Ledin, Lina Mattson, Antonio Lentini, Mikael Benson, Danuta R. Gawel, Zou Xiang, Janne Björkander, Tejaswi V. S. Badam, Huan Zhang, Jordi Serra-Musach, Mika Gustafsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Adult 0301 basic medicine Article Subject medicine.medical_treatment Immunology Cell medicine.disease_cause Interferon-gamma 03 medical and health sciences Th2 Cells Allergen Interferon medicine Humans Immunology and Allergy Gene Betula Cells Cultured Dominance (genetics) Principal Component Analysis business.industry Interferon-alpha Rhinitis Allergic Seasonal STAT2 Transcription Factor Interferon-beta General Medicine Immunotherapy Middle Aged Th1 Cells Gene expression profiling STAT1 Transcription Factor 030104 developmental biology medicine.anatomical_structure Other Clinical Medicine Leukocytes Mononuclear Annan klinisk medicin Pollen Female lcsh:RC581-607 business Interferon type I Research Article Signal Transduction medicine.drug |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2016 (2016) |
| ISSN: | 2314-8861 |
| DOI: | 10.1155/2016/5153184 |
| Popis: | Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive Tcells into Th1 cells. As SIT is thought to cause a shift towardsTh1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4(+) T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies. Funding Agencies|Swedish Research Council [2015-02575] |
| Databáze: | OpenAIRE |
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