Realization of High Regioselectivity in the Coupling Reaction of a Cyclopentadiene Monoepoxide Equivalent and Aryl Nucleophiles

Autor:	Eisuke Takahisa, Shahid B. Usmani, Yuichi Kobayashi
Jazyk:	angličtina
Rok vydání:	1998
Předmět:	Cyclopentadiene Aryl Organic Chemistry Regioselectivity chemistry.chemical_element Biochemistry Combinatorial chemistry Coupling reaction Catalysis chemistry.chemical_compound chemistry Nucleophile Drug Discovery Lithium Realization (systems)
Zdroj:	Tetrahedron Lett.. 39:597-600
ISSN:	0040-4039
Popis:	Coupling reaction of monoacetate 2 and aryl hard nucleophiles is realized for the first time, which consists of the lithium arylborates as hard nucleophiles and NiCl2(PPh3)2 as a catalyst. More importantly, the independent effects of t-BuCN and NaI and their synergistic function are discovered to increase regioselectivity furnishing trans 1,3-isomers 6 as the major products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3ca0f0e5f4f01f66a77230d1bcb2d8 http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100417868 Zobrazit plný text záznamu Full Text from ScienceDirect