Self-assembled fluorescent organic nanoparticles for live cell imaging

Autor:	Yvonne L. Dorland, Luc Brunsveld, Irén Fischer, Katja Petkau-Milroy, Aphj Albert Schenning
Přispěvatelé:	Stimuli-responsive Funct. Materials & Dev., Chemical Biology, Biomedical Engineering, Macromolecular and Organic Chemistry
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Cell Survival Supramolecular chemistry Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Flow cytometry Self assembled Live cell imaging medicine Humans Amines Fluorescent Dyes Microscopy Confocal medicine.diagnostic_test Chemistry Cellular imaging Optical Imaging Organic Chemistry General Chemistry Flow Cytometry 021001 nanoscience & nanotechnology Fluorescence 0104 chemical sciences Biophysics Nanoparticles Self-assembly 0210 nano-technology HeLa Cells
Zdroj:	Chemistry : A European Journal, 19(49), 16646-16650. Wiley-VCH Verlag
ISSN:	1521-3765 0947-6539
Popis:	Fluorescent, cell-permeable, organic nanoparticles based on self-assembled p-conjugated oligomers with high absorption cross-sections and high quantum yields have been developed. The nanoparticles are generated with a tuneable density of amino groups for charge-mediated cellular uptake by a straightforward self-assembly protocol, which allows for control over size and toxicity. The results show that a single amino group per ten oligomers is sufficient to achieve cellular uptake. The non-toxic nanoparticles are suitable for both one- and two-photon cellular imaging and flow cytometry, and undergo very efficient cellular uptake.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3b3929e532ceafce32aa4ecbca7c8f https://research.tue.nl/en/publications/f91862dd-13a9-4ff1-bc41-9c0e41fc5968 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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