Synthesis and biological activities of new hydrazide derivatives
Autor: | Yağmur Tunalı, Gülhan Turan-Zitouni, Zafer Asım Kaplancıklı, Ahmet Özdemir |
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Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Özdemir, Ahmet, Turan, Gülhan, Kaplancıklı, Zafer Asım, Tunalı, Yağmur |
Rok vydání: | 2009 |
Předmět: |
Magnetic Resonance Spectroscopy
Turkey Proteus vulgaris Antitubercular Agents Microbial Sensitivity Tests Biology medicine.disease_cause Antimicrobial Activity Mass Spectrometry Enterococcus faecalis Microbiology Mycobacterium tuberculosis Structure-Activity Relationship Anti-Infective Agents Imidazo[1 2-A]Pyrazine Drug Discovery medicine Humans Candida albicans Antituberculosis Activity Pharmacology Hydrazide Bacteria Candida glabrata Fungi Imidazoles General Medicine biology.organism_classification Hydrazines Staphylococcus aureus Antibacterial activity |
Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry. 24:825-831 |
ISSN: | 1475-6374 1475-6366 |
DOI: | 10.1080/14756360802399712 |
Popis: | WOS: 000266040700028 PubMed ID: 18825530 The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their biological activity against various bacteria, fungi species, and Mycobacterium tuberculosis was investigated. Antibacterial activity was measured against Escherichia coli (NRRL B-3704), Staphylococcus aureus (NRRL B-767), Salmonella typhimurium (NRRL B-4420), Proteus vulgaris (NRLL B-123), Enterococcus faecalis (isolated obtained from Faculty of Medicine Osmangazi University, Eskisehir, Turkey), Pseudomonas aeruginosa (NRRL B-23 27853), Klebsiella spp. (isolated obtained from Faculty of Medicine Osmangazi University, Eskisehir, Turkey), while antifungal activity was evaluated against Candida albicans (isolates obtained from Osmangazi Uni. Fac. of Medicine), Candida glabrata (isolates obtained from Osmangazi Uni. Fac. of Medicine). Compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The compounds showed moderate inhibitor effects against human pathogenic microorganisms., whereas the preliminary results indicated that all of the tested compounds were inactive against Mycobacterium tuberculosis H(37)Rv. |
Databáze: | OpenAIRE |
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