Synthesis and biological activities of new hydrazide derivatives

Autor: Yağmur Tunalı, Gülhan Turan-Zitouni, Zafer Asım Kaplancıklı, Ahmet Özdemir
Přispěvatelé: Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Özdemir, Ahmet, Turan, Gülhan, Kaplancıklı, Zafer Asım, Tunalı, Yağmur
Rok vydání: 2009
Předmět:
Zdroj: Journal of Enzyme Inhibition and Medicinal Chemistry. 24:825-831
ISSN: 1475-6374
1475-6366
DOI: 10.1080/14756360802399712
Popis: WOS: 000266040700028
PubMed ID: 18825530
The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their biological activity against various bacteria, fungi species, and Mycobacterium tuberculosis was investigated. Antibacterial activity was measured against Escherichia coli (NRRL B-3704), Staphylococcus aureus (NRRL B-767), Salmonella typhimurium (NRRL B-4420), Proteus vulgaris (NRLL B-123), Enterococcus faecalis (isolated obtained from Faculty of Medicine Osmangazi University, Eskisehir, Turkey), Pseudomonas aeruginosa (NRRL B-23 27853), Klebsiella spp. (isolated obtained from Faculty of Medicine Osmangazi University, Eskisehir, Turkey), while antifungal activity was evaluated against Candida albicans (isolates obtained from Osmangazi Uni. Fac. of Medicine), Candida glabrata (isolates obtained from Osmangazi Uni. Fac. of Medicine). Compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The compounds showed moderate inhibitor effects against human pathogenic microorganisms., whereas the preliminary results indicated that all of the tested compounds were inactive against Mycobacterium tuberculosis H(37)Rv.
Databáze: OpenAIRE
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