| Autor: |
Peixu Zhao, Wen Han, Yecheng Shu, Mo Li, Yichi Sun, Xiaofan Sui, Bingyang Liu, Baocheng Tian, Yanhua Liu, Qiang Fu |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of controlled release : official journal of the Controlled Release Society. 353 |
| ISSN: |
1873-4995 |
| Popis: |
As a promising strategy, amorphous solid dispersion has been extensively employed in improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the problems associated with supersaturation stability limit its further application. Recently, the formation and stability of the liquid-liquid phase separation drug aggregate (LLPS-DA) have been found to be vital for supersaturation maintenance. An in-depth review of LLPS-DA was required to further explore the supersaturation maintenance mechanism in vivo. Hence, this study aimed to present a short review to introduce the LLPS-DA, highlight the in vivo advantages for oral administration, and discuss the prospects to help understand the in vivo behavior of LLPS-DA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect