Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control
| Autor: | Eicke Latz, Tomasz Próchnicki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physiology immunology [NLR Family Pyrin Domain-Containing 3 Protein] Inflammasomes metabolism [NLR Family Pyrin Domain-Containing 3 Protein] NLRP12 protein human Mitochondrion Biology metabolism [Bacteria] Pyrin domain 03 medical and health sciences AIM2 NLRC4 immunology [Intracellular Signaling Peptides and Proteins] ddc:570 immunology [Bacterial Infections] NLR Family Pyrin Domain-Containing 3 Protein medicine Animals Humans Molecular Biology microbiology [Mitochondria] NLRP6 Innate immune system Bacteria NLRP1 Intracellular Signaling Peptides and Proteins Inflammasome Bacterial Infections Cell Biology immunology [Mitochondria] metabolism [Mitochondria] Immunity Innate Mitochondria Cell biology Gastrointestinal Microbiome immunology [Inflammasomes] NLRP6 protein human 030104 developmental biology immunology [Bacteria] metabolism [Bacterial Infections] Host-Pathogen Interactions Glycolysis metabolism [Inflammasomes] metabolism [Intracellular Signaling Peptides and Proteins] Metabolic Networks and Pathways medicine.drug |
| Zdroj: | Cell metabolism 26(1), 71-93 (2017). doi:10.1016/j.cmet.2017.06.018 |
| DOI: | 10.1016/j.cmet.2017.06.018 |
| Popis: | Inflammasomes are protein complexes formed upon encounter of microbial or damage-associated stimuli. The main output of inflammasome assembly is activation of caspase-1, a protease involved in both pro-inflammatory and host-protective responses. Defined bacterial or viral ligands have been identified for the inflammasome-forming receptors AIM2, NLRP1, and NLRC4. The signals activating other inflammasomes, NLRP3, NLRP6, and pyrin, are less well understood. Recent studies implicated several low-molecular-weight compounds traditionally linked to metabolism, not immunity, in modulation of inflammasome signaling. Furthermore, genetic, pharmacological, or pathogen-mediated interference with energy metabolism also affects inflammasome activation. Here we review the findings on how microbial- and host-derived metabolites regulate activation of the NLRP3 and NLRP6 inflammasomes. We discuss the different models of how glycolysis and mitochondrial metabolism control the NLRP3 inflammasome. Finally, we summarize the findings on metabolic control of pyrin and point to open questions to be addressed to broaden our understanding of metabolism-inflammasome interactions. |
| Databáze: | OpenAIRE |
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