Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

Autor:	Eun-Hye Lee, Soo Jung Ryu, Dahye Lee, Jin Hee Ahn, Myung Ae Bae, Geum Ran Kim, Don Hang Lee, Minhee Kim, Suvarna H. Pagire, Jin Sook Song, Kyu-Seok Hwang, Sukyung Ahn, Jin Hee Maeng, Haushabhau S. Pagire, Eun Jung Bae
Rok vydání:	2018
Předmět:	Lipopolysaccharides 0301 basic medicine Antioxidant Cell Survival medicine.drug_class medicine.medical_treatment Clinical Biochemistry Glutamic Acid Pharmaceutical Science Biochemistry Antioxidants Anti-inflammatory Mice Structure-Activity Relationship 03 medical and health sciences Picrates Drug Discovery medicine Animals Cytotoxicity Molecular Biology Zebrafish Dose-Response Relationship Drug Molecular Structure Chemistry Anti-Inflammatory Agents Non-Steroidal Biphenyl Compounds Organic Chemistry In vitro RAW 264.7 Cells 030104 developmental biology Design synthesis Cell culture Drug Design Molecular Medicine Chemical stability Glutamic Acid Derivatives
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 28:529-532
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2017.11.012
Popis:	A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df350a91c55de39b724462151aeb47b6 https://doi.org/10.1016/j.bmcl.2017.11.012 Zobrazit plný text záznamu Full Text from ScienceDirect