Osteoimmunopathology in HIV/AIDS: A Translational Evidence-Based Perspective
| Autor: | Linda Phi, Ercolano Manfrini, Andre Barkhordarian, Negoita Neagos, Muniza Siddiqui, Nora Ghodousi, Amy Giroux, Xenia Maria Caldeira Brant, Olivia S. Cajulis, Nicole Mahanian, Paul Shapshak, Natasha Iyer, Francesco Chiappelli, Manisha Ramchandani, G. Gary Demerjian, Riana Cayabyab, Reem Ajaj, Sohrab Danaie |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Comparative Effectiveness Research
Cellular immunity Evidence-based practice Osteoporosis Review Article Bioinformatics Pathology and Forensic Medicine Bone remodeling Acquired immunodeficiency syndrome (AIDS) Clinical Research medicine lcsh:Pathology 2.1 Biological and endogenous factors In patient Aetiology business.industry Perspective (graphical) medicine.disease Infectious Diseases Systematic review Musculoskeletal HIV/AIDS Infection business lcsh:RB1-214 |
| Zdroj: | Pathology Research International, Vol 2011 (2011) Pathology Research International |
| Popis: | Infection with the human immunodeficiency virus-1 (HIV) and the resulting acquired immune deficiency syndrome (AIDS) alter not only cellular immune regulation but also the bone metabolism. Since cellular immunity and bone metabolism are intimately intertwined in the osteoimmune network, it is to be expected that bone metabolism is also affected in patients with HIV/AIDS. The concerted evidence points convincingly toward impaired activity of osteoblasts and increased activity of osteoclasts in patients with HIV/AIDS, leading to a significant increase in the prevalence of osteoporosis. Research attributes these outcomes in part at least to the ART, PI, and HAART therapies endured by these patients. We review and discuss these lines of evidence from the perspective of translational clinically relevant complex systematic reviews for comparative effectiveness analysis and evidence-based intervention on a global scale. |
| Databáze: | OpenAIRE |
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