Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
| Autor: | Cláudia Cavadas, Ana Rita Álvaro, Alexandrina Ferreira Mendes, Cátia Sousa, Laetitia S. Gaspar |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Aging Osteoarthritis Comorbidity Social burden 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology medicine Animals Humans Pharmacological modulation Intensive care medicine Depression (differential diagnoses) Pharmacology Sleep Apnea Obstructive business.industry medicine.disease Obstructive sleep apnea Sleep deprivation 030104 developmental biology 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Pharmacological research. 164 |
| ISSN: | 1096-1186 |
| Popis: | Osteoarthritis (OA) and Obstructive Sleep Apnea (OSA) are two highly prevalent chronic diseases for which effective therapies are urgently needed. Recent epidemiologic studies, although scarce, suggest that the concomitant occurrence of OA and OSA is associated with more severe manifestations of both diseases. Moreover, OA and OSA share risk factors, such as aging and metabolic disturbances, and co-morbidities, including cardiovascular and metabolic diseases, sleep deprivation and depression. Whether this coincidental occurrence is fortuitous or involves cause-effect relationships is unknown. This review aims at collating and integrating present knowledge on both diseases by providing a brief overview of their epidemiology and pathophysiology, analyzing current evidences relating OA and OSA and discussing potential common mechanisms by which they can aggravate each other. Such mechanisms constitute potential therapeutic targets whose pharmacological modulation may provide more efficient ways of reducing the consequences of OA and OSA and, thus, lessen the huge individual and social burden that they impose. |
| Databáze: | OpenAIRE |
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