Natural history of subaortic stenosis in 166 dogs (1999-2011)
| Autor: | Kenneth E. Lamb, Christopher D. Stauthammer, D. Leeder, D.M. Fine-Ferreira, Anthony H. Tobias, B.D. Eason |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Heart Defects
Congenital medicine.medical_specialty General Veterinary Physiology business.industry Severe disease Age at diagnosis Constriction Pathologic Cardiomyopathy Hypertrophic medicine.disease Aortic Stenosis Subvalvular Severity of Illness Index Natural history Stenosis Dogs Disease severity Internal medicine Medicine Animals Dog Diseases business Subaortic stenosis Median survival Survival analysis |
| Zdroj: | Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 37 |
| ISSN: | 1875-0834 |
| Popis: | Subaortic stenosis (SAS) is one of the most common congenital cardiac diseases in dogs. The objective of this study was to provide survival times on a large population of dogs with SAS and to propose a redefined pressure gradient (PG) scale to include a mild, moderate, severe and very severe disease group.Dogs were divided into four groups based on the Doppler-derived PG across the stenosis. Disease severity was defined as follows: mild = PG 50 mmHg; moderate = PG range 50-80 mmHg; severe = PG range 80-130 mmHg; and very severe = PG 130 mmHg. Over the study period (1999-2011), 166 client-owned dogs were diagnosed with SAS of which 129 had follow-up information available.Unadjusted median survival time for severity groups were as follows: mild 10.6 years; moderate 9.9 years; severe 7.3 years; and very severe 3.0 years. Univariable analysis examining the effect of the PG, age at diagnosis and sex found only the PG and age at diagnosis had a significant effect on survival. Adjusted survival curves showed that the survival time in the very severe group was decreased compared with all other groups.Based on the results of this study, a revised SAS classification system with four PG groups is appropriate. Dogs with a PG 130 mmHg were identified as those with the lowest median survival time. |
| Databáze: | OpenAIRE |
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