Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico

Autor: Montserrat Torremorell, Albert Rovira, Marie R. Culhane, Nídia S. Trovão, Amy L. Vincent, Ignacio Mena, Martha I. Nelson, Andres Diaz, Carine K. Souza, Douglas Marthaler
Rok vydání: 2019
Předmět:
Epidemiology
viruses
Reassortment
lcsh:Medicine
phylogeography
medicine.disease_cause
Genome
influenza virus
Antigenic Diversity
Influenza A Virus
H1N1 Subtype
vaccine
Pandemic
Influenza A virus
Antigens
Viral
reverse zoonosis
human origin
virus diseases
Infectious Diseases
Influenza Vaccines
antigenic cartography
influenza
Reassortant Viruses
Microbiology (medical)
Biology
Virus
lcsh:Infectious and parasitic diseases
respiratory infections
Orthomyxoviridae Infections
evolution
Influenza
Human
medicine
Animals
Humans
influenza A virus
lcsh:RC109-216
Mexico
Genetic diversity
Research
phylogenetic analysis
pandemic
Influenza A Virus
H3N2 Subtype
lcsh:R
swine
Virology
zoonoses
reassortant influenza viruses
reassortment
Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine
Southeast Mexico
Zdroj: Emerging Infectious Diseases, Vol 25, Iss 4, Pp 691-700 (2019)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
DOI: 10.3201/eid2504.180779
Popis: The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and evaluate strains for vaccine development, we sequenced the genomes of 59 viruses and performed antigenic cartography on strains from 5 regions. We found that genetic and antigenic diversity were particularly high in southeast Mexico because of repeated introductions of viruses from humans and swine in other regions in Mexico. We identified novel reassortant H3N2 viruses with genome segments derived from 2 different viruses that were independently introduced from humans into swine: pandemic H1N1 viruses and seasonal H3N2 viruses. The Mexico swine viruses are antigenically distinct from US swine lineages. Protection against these viruses is unlikely to be afforded by US virus vaccines and would require development of new vaccines specifically targeting these diverse strains.
Databáze: OpenAIRE
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