Pancreastatin-like immunoreactivity of cerebrospinal fluid in patients with Alzheimer type dementia: evidence of aberrant processing of pancreastatin in Alzheimer type dementia
| Autor: | Kayoko Tateishi, Shinnosuke Kurose, Hajime Nawata, Ryoichi Takayanagi, Kensaku Sekiya, Masanobu Oyama, Masao Ohashi, Motofumi Fukahori, Masafumi Haji, Akihiro Funakoshi |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Pathology Central nervous system Alzheimer type dementia Pancreastatin Cerebrospinal fluid Degenerative disease Alzheimer Disease Internal medicine Humans Medicine In patient Aged Aged 80 and over biology business.industry General Neuroscience fungi food and beverages Chromogranin A Middle Aged Pancreatic Hormones medicine.disease Molecular Weight Endocrinology medicine.anatomical_structure Chromatography Gel biology.protein Female Alzheimer's disease business Protein Processing Post-Translational |
| Zdroj: | Neuroscience Letters. 177:123-126 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(94)90060-4 |
| Popis: | The concentrations of pancreastatin-like immunoreactivity (PST-LI) of the cerebrospinal fluid (CSF) were measured in the patients with Alzheimer type dementia (ATD) and in age-matched normal subjects. The mean PST-LI concentration in the CSF of ATD patients was significantly lower than that of normal subjects. Gel chromatographic analysis revealed that the main PST-LI peak of ATD's CSF eluted at molecular weight (MW) 13.5 kDa. However, the age-related change of the molecular forms of PST-LI in CSF was observed in normal subjects as following; PST-LI in neonatal CSF showed one peak at MW 13.5 kDa, that of 16-64-year-old showed two peaks at MW 13.5 and 5.4 kDa, however, only one main peak was shown at MW 5.4 kDa in the CSFs of 72-85-year-old. These findings suggest that the production of PST-LI was decreased and the proteolytic cleavage, which should process big PST to PST (1-52) in normal subjects, was altered to that of neonatal type in the CNS of the patients with ATD. |
| Databáze: | OpenAIRE |
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