GABAB receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats
| Autor: | Ji-Wang Zheng, Su-Min Li, Lin-Lin Yin, Yan-Hua Ren, Li-Shan Pan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Agonist Baclofen Dextroamphetamine medicine.drug_class Craving GABAB receptor Pharmacology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Conditioning Psychological medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics Dose-Response Relationship Drug business.industry General Medicine Preference Conditioned place preference Rats chemistry GABA-B Receptor Agonists Systemic administration Conditioning medicine.symptom business Reinforcement Psychology |
| Zdroj: | Life Sciences. 70:349-356 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(01)01397-2 |
| Popis: | The present study investigated the effect of systemic administration of the GABA(B) receptor agonist, baclofen, on the development and expression of d-methamphetamine (d-MA)-induced place preference in male Wistar rats. Using a biased and 8-day schedule of conditioning, it was found that administration of d-MA (0.5 mg/kg, i.p.) produced significant place preference. The administration of baclofen (2.5 and 5.0 mg/kg, i.p.) 30 min prior to the exposure to d-MA attenuated the development of d-MA-induced place preference (p0.05). In addition, when it was acutely administered 30 min prior to the testing session of an already established d-MA place preference, baclofen (1.25-5.0 mg/kg, i.p.) attenuated the expression of this conditioned response in a dose-dependent manner. These results showed that baclofen suppressed the rewarding effect produced by d-MA and may be potentially effective in the treatment of methamphetamine dependence and craving. |
| Databáze: | OpenAIRE |
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