Hunner lesion disease differs in diagnosis, treatment and outcome from bladder pain syndrome: an ESSIC working group report

Autor:	Paulo Dinis Oliveira, Jörgen Quaghebeur, Hikaru Tomoe, Yr Logadottir, Magnus Fall, Robert M. Moldwin, Tomohiro Ueda, Jane Meijlink, Jean-Jacques Wyndaele, Philip M. Hanno, Kristene Whitmore, Andrew Zaitcev, Mauro Cervigni, Rajesh Taneja, Jennifer Yonaitis Fariello, Loredana Nasta, Gjertrud Wennevik, Nagendra Mishra, Vicki Ratner, Jørgen Nordling, Jukka Sairanen, Christina Kåbjörn-Gustafsson
Rok vydání:	2020
Předmět:	Research Report medicine.medical_specialty Urology 030232 urology & nephrology Cystitis Interstitial Physical examination Disease 030204 cardiovascular system & hematology urologic and male genital diseases Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Humans medicine.diagnostic_test business.industry Interstitial cystitis Cystoscopy medicine.disease Dermatology Endoscopy Natural history Treatment Outcome Nephrology Histopathology Human medicine business hormones hormone substitutes and hormone antagonists
Zdroj:	Scandinavian journal of urology
ISSN:	2168-1813 2168-1805
Popis:	Objectives: There is confusion about the terms of bladder pain syndrome (BPS) and Interstitial Cystitis (IC). The European Society for the Study of IC (ESSIC) classified these according to objective findings [9]. One phenotype, Hunner lesion disease (HLD or ESSIC 3C) differs markedly from other presentations. Therefore, the question was raised as to whether this is a separate condition or BPS subtype. Methods: An evaluation was made to explore if HLD differs from other BPS presentations regarding symptomatology, physical examination findings, laboratory tests, endoscopy, histopathology, natural history, epidemiology, prognosis and treatment outcomes. Results: Cystoscopy is the method of choice to identify Hunner lesions, histopathology the method to confirm it. You cannot distinguish between main forms of BPS by means of symptoms, physical examination or laboratory tests. Epidemiologic data are incomplete. HLD seems relatively uncommon, although more frequent in older patients than non-HLD. No indication has been presented of BPS and HLD as a continuum of conditions, one developing into the other. Conclusions: A paradigm shift in the understanding of BPS/IC is urgent. A highly topical issue is to separate HLD and BPS: treatment results and prognoses differ substantially. Since historically, IC was tantamount to Hunner lesions and interstitial inflammation in the bladder wall, still, a valid definition, the term IC should preferably be reserved for HLD patients. BPS is a symptom syndrome without specific objective findings and should be used for other patients fulfilling the ESSIC definitions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2e71ec674f9dc905d2efba324472e8 https://pubmed.ncbi.nlm.nih.gov/34130491 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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